The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512
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- 作者：Hassan Mziaut1 ; 2 ; Bernard Mulligan1 ; 2 ; Peter Hoboth1 ; 2 ; Oliver Otto3 ; Anna Ivanova1 ; 2 ; Maik Herbig3 ; Desiree Schumann4 ; Tobias Hildebrandt4 ; Jaber Dehghany5 ; Anke Sö ; nmez1 ; 2 ; Carla Mü ; nster1 ; 2 ; Michael Meyer-Hermann5 ; Jochen Guck3 ; Yannis Kalaidzidis6 ; Michele Solimena1 ; 2 ; 6 ; Michele.Solimena@tu-dresden.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：F-actin ; Granules ; Ica512 ; Insulin ; Secretion ; Villin
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：5
- 期：8
- 页码：656-668
- 全文大小：3690 K
文摘
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Ica512-depletion reduces the genetic expression of the F-actin modifier villin.
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Villin-depletion enhances basal insulin granule mobility and exocytosis.
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Villin regulates the size of actin cages restraining insulin granules.
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Villin acts downstream of insulin granule cargo Ica512.
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The Ica512-villin genetic link enables granules to control cytoskeleton plasticity.