HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma
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- 作者：Yanxin Pei1 ; 2 ; 13 ; Kun-Wei Liu1 ; 13 ; Jun Wang1 ; Alexandra Garancher1 ; Ran Tao2 ; Lourdes A. Esparza1 ; Donna L. Maier1 ; Yoko T. Udaka3 ; Najiba Murad2 ; Sorana Morrissy4 ; Huriye Seker-Cin5 ; 6 ; Sebastian Brabetz5 ; 6 ; Lin Qi7 ; Mari Kogiso7 ; Simone Schubert8 ; James M. Olson9 ; Yoon-Jae Cho8 ; Xiao-Nan Li7 ; John R. Crawford3 ; 10 ; Michael L. Levy11 ; Marcel Kool5 ; 6 ; Stefan M. Pfister5 ; 6 ; Michael D. Taylor4 ; 12 ; Robert J. Wechsler-Reya1 ; rwreya@sbpdiscovery.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：14 March 2016
- 年：2016
- 卷：29
- 期：3
- 页码：311-323
- 全文大小：3540 K
文摘
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High-throughput screening identifies inhibitors of MYC-driven MB
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HDACIs inhibit growth of murine and human MYC-driven MB cells
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HDACIs and PI3KIs cooperate to activate FOXO1 and suppress tumor growth in vitro
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HDACIs and PI3KIs inhibit growth of MYC-driven tumors in vivo