Pore expansion of highly monodisperse phenylene-bridged organosilica spheres for chromatographic application

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• 作者：Yongping Zhang ; Yu Jin ; Hui Yu ; Peichun Dai ; Yanxiong Ke ; Xinmiao Liang
• 关键词：Phenylene-bridged ; Hybrid organosilica ; Spheres ; Pore expansion ; HPLC
• 刊名：Talanta
• 出版年：2010
• 出版时间：15 May 2010
• 年：2010
• 卷：81
• 期：3
• 页码：824-830
• 全文大小：1031 K

文摘

Monodisperse phenylene-bridged organosilica spheres show great potential as chromatographic stationary phase. In this paper, the tunable particle size of monodisperse phenylene-bridged organosilica spheres were prepared by co-condensing different proportion of 1,4-bis(triethoxysilyl)benzene (1,4-BTEB) and tetraethylorthosilicate (TEOS), and then pore size was expanded by two-step post-synthesis hydrothermal treatments using N,N-dimethyldecylamine (DMDA)/dodecylamine (DDA) and tris-(hydroxymethyl)-aminomethane (TRIS) in turn. Phenylene-bridged organosilica spheres with particle size of 3.0–3.5 μm and pore size of 85 Å were further surface modified by C₁₈ group and tested in reversed-phase high performance liquid chromatography (RP-HPLC). The primary chromatographic results demonstrated that C₁₈ bonded phenylene-bridged organosilica stationary phase has high retention and good chemical stability in the high pH mobile phase, which indicated that the phenylene-bridged organosilica can be used for HPLC packing supports.