Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice
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- 作者：Wen Hua ; 1 ; Yaodong Zhanga ; 1 ; Wenning Wua ; 1 ; Yanyan Yina ; Dake Huangb ; Yuchan Wanga ; Weiping Lia ; Weizu Lia ; liweizu@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glucocorticoids ; Locomotor behavior ; NLRP1 inflammasome ; Neurodegenerative diseases ; Neuroinflammation ; Alzheimer&rsquo ; s disease
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：52
- 期：Complete
- 页码：58-70
- 全文大小：4551 K
文摘
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Chronic GCs exposure enhances neurodegeneration in cortex and hippocampus.
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Chronic GCs exposure decreases expression of GR and MAP2 in cortex and hippocampus.
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Chronic GCs exposure increases expression of NLRP1 and ASC in cortex and hippocampus.
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Chronic GCs exposure increases expression of IL-1β and IL-6 in cortex and hippocampus.
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Chronic GCs exposure increases brain inflammation via NLRP1 inflammasome activation.