Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC1R) gene in Tibetan pigs and Landrace pigs
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- 作者：Rui Liua ; b ; 1 ; Long Jina ; b ; 1 ; Keren Longa ; b ; Jie Chaia ; b ; Jideng Maa ; b ; Qianzi Tanga ; b ; Shilin Tiana ; b ; c ; Yaodong Hua ; b ; Ling Linc ; Xun Wanga ; b ; Anan Jianga ; b ; Xuewei Lia ; b ; lixuewei9125@126.com" class="auth_mail" title="E-mail the corresponding author ; Mingzhou Lia ; b ; mingzhou.li@sicau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：MC1R ; melanocortin 1 receptor ; E ; Extension ; ASIP ; agouti signaling protein ; TYRP1 ; tyrosinase related protein 1 ; EDNRB ; endothelin receptor beta ; KITLG ; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog ; OCA2 ; oculocutaneous albinism II ; CDS ; coding region sequence ; PCR ; polymerase chain reaction ; SNP ; single nucleotide polymorphism ; dN ; the relative frequencies of non-synonymous ; dS ; the relative frequencies of synonymous
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：537-542
- 全文大小：441 K
文摘
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Genetic variability at the MC1R is lower in European white Landrace pigs than in Asian black Tibetan pigs.
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Tibetan pigs possessed shared haplotypes, suggesting a possibility of recent introgression event.
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We detected positive selection at the MC1R in both Tibetan pigs and Landrace pigs through the dN /dS analysis.
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Eurasian wild boars may have initially experienced different selection and MC1R alleles diversified in modern domestication.