Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

详细信息    查看全文

• 作者：Huidong Zheng^a ; Yuanyuan Huang^a ; Zhiwei Wang^a ; Huaifeng Li^b ; Kuo-Wei Huang^b ; ^{hkw@kaust.edu.sa} ; Yaofeng Yuan^a ; Zhiqiang Weng^a ; ^{zweng@fzu.edu.cn}
• 关键词：Copper catalysis ; Trifluoromethylated acetylenes ; Trifluoromethylation ; Alkynyltrifluoroborates
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：5 December, 2012
• 年：2012
• 卷：53
• 期：49
• 页码：6646-6649
• 全文大小：2325 K

文摘

A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed.