The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis
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- 作者：Shilpy Joshi1 ; 7 ; Denis Tolkunov1 ; 7 ; Hana Aviv2 ; Abraham A. Hakimi3 ; Ming Yao1 ; James J. Hsieh4 ; Shridar Ganesan1 ; 5 ; Chang S. Chan1 ; 5 ; chanc3@cinj.rutgers.edu" class="auth_mail" title="E-mail the corresponding author ; Eileen White1 ; 6 ; epwhite@cinj.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：oncocytoma ; cancer metabolism ; mitochondria ; cancer genomics ; lysosome
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：13
- 期：9
- 页码：1895-1908
- 全文大小：5794 K
文摘
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Type 2 renal oncocytoma may precede eosinophilic ChRCC
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Mitochondrial defects disrupt Golgi organization and trafficking
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Mitochondrial accumulation in oncocytomas is due to defective elimination
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Impaired mitochondrial function is a barrier to tumorigenesis