KLF15 regulates slow myosin heavy chain expression through NFATc1 in C2C12 myotubes
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- 作者：Jie Wang ; Ting Chen ; Fu Feng ; Huan Wei ; Weijun Pang ; Gongshe Yang ; Qingwu W. Shen ; yaoyao3153@aliyun.com" class="auth_mail
- 关键词：KLF15 ; Myosin heavy chain ; NFAT ; C2C12 myotubes
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：18 April 2014
- 年：2014
- 卷：446
- 期：4
- 页码：1231-1236
- 全文大小：910 K
文摘
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Higher expression of KLF15 was detected in slow than in fast muscles.
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KLF15 did not regulate myogenic differentiation of C2C12 cells.
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KLF15 upregulated slow myosin heavy chain expression in C2C12 myotubes.
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KLF15 regulated NFATc1 expression by direct binding and activating Nfatc1 promoter.
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KLF15 upregulated slow myosin heavy chain expression through NFATc1.