Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats
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- 作者：Dongmei Wang ; Yaping Xue ; Yajuan Chen ; Liqin Ruan ; Yanguo Hong ; yhong@fjnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; f22868211@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dorsal root ganglion (DRG) ; Mas-related gene (Mrg) receptor ; Microglia ; Neuropathic pain ; Spinal dorsal horn
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：8 April 2016
- 年：2016
- 卷：618
- 期：Complete
- 页码：115-121
- 全文大小：1258 K
文摘
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Intrathecal (i.t.) administration of BAM8-22 inhibited mechanical allodynia on day 2 post-SNL surgery.
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I.t. BAM8-22 reversed microglia activation in the spinal dorsal horn.
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I.t. BAM8-22 suppressed expression of nNOS in the dorsal root ganglion (DRG).
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L5 SNL reduced the level of MrgC receptor mRNA in the injured L5 DRG, but not the uninjured adjacent L4 or L6 DRG, on day 2 post-SNL.
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This study suggests that MrgC receptors could be targeted as a novel therapy for neuropathic pain with limited unwanted effects.