ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation
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- 作者：Hu Chen ; Renqiang Yuan ; Ying Zhang ; Xumeng Zhang ; Luxi Chen ; Xingyu Zhou ; Zhuning Yuan ; Yaping Nie ; Ming Li ; Delin Mo ; modelin@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yaosheng Chen ; chyaosh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：USP7 ; ubiquitin specific peptidase 7 ; TRB3 ; tribbles homolog 3 ; PTM ; post-translational modification ; IBMX ; 1-methyl-3-isobutylxanthine ; DEX ; dexamethasone ; INS ; insulin
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：1859
- 期：11
- 页码：1459-1469
- 全文大小：1864 K
文摘
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Depletion of ATF4 decreased SREBP1c protein while increased Srebp1c mRNA.
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USP7 was identified as a novel target of ATF4.
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USP7 deubiquitinated SREBP1c protein and increased its level in cell.
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ATF4 inhibited Srebp1c transcription via TRB3.
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TRB3 was repressed by IBMX and DEX at early adipogenesis.