Dual-controlled release system of drugs for bone regeneration

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• 作者：Yang-Hee Kim ; Yasuhiko Tabata ; ^{yasuhiko@frontier.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dual release ; Angiogenesis ; Osteogenesis ; Bioactive molecules ; Bone regeneration
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2015
• 出版时间：1 November 2015
• 年：2015
• 卷：94
• 期：Complete
• 页码：28-40
• 全文大小：919 K

文摘

Controlled release systems have been noted to allow drugs to enhance their ability for bone regeneration. To this end, various biomaterials have been used as the release carriers of drugs, such as low-molecular-weight drugs, growth factors, and others. The drugs are released from the release carriers in a controlled fashion to maintain their actions for a long time period. Most research has been focused on the controlled release of single drugs to demonstrate the therapeutic feasibility. Controlled release of two combined drugs, so-called dual release systems, are promising and important for tissue regeneration. This is because the tissue regeneration process of bone formation is generally achieved by multiple bioactive molecules, which are produced from cells by other molecules. If two types of bioactive molecules, (i.e., drugs), are supplied in an appropriate fashion, the regeneration process of living bodies will be efficiently promoted. This review focuses on the bone regeneration induced by dual-controlled release of drugs. In this paper, various dual-controlled release systems of drugs aiming at bone regeneration are overviewed explaining the type of drugs and their release materials.