Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures
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- 作者：Yasuhiro Ishiharaa ; ishiyasu@hiroshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Noriko Fujitania ; Hikaru Sakuraia ; Takuya Takemotoa ; Nami Ikeda-Ishiharab ; Kanami Mori-Yasumotoc ; Tatsuo Nehiraa ; Atsuhiko Ishidaa ; Takeshi Yamazakia
- 关键词：DG ; dentate gyrus ; GPER/GPR30 ; G-protein coupled estrogen receptor/receptor 30 ; 17β-HSD2 ; 17β-hydroxysteroid dehydrogenase 2 ; OGD ; oxygen-glucose deprivation ; PI ; propidium iodide
- 刊名：Steroids
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：71-77
- 全文大小：958 K
文摘
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Progesterone suppresses neuronal injury via progesterone receptor with genomic action.
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Allopregnanolone converted from progesterone shows neuroprotective effect.
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Testosterone protects neurons via its genomic action mediated by androgen receptor.
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Dihydrotestosterone converted from testosterone exhibits neuroprotective action.
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Estradiol neuroprotection is independent of estrogen receptors and genomic action.