Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers

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• 作者：Woraphat Ratta-apha ; Akitoyo Hishimoto ; Kentaro Mouri ; Kyoichi Shiroiwa ; Toru Sasada ; Masakuni Yoshida ; Satoshi Okazaki ; Irwan Supriyanto ; Migiwa Asano ; Yasuhiro Ueno ; Osamu Shirakawa ; Ichiro Sora
• 关键词：Disrupted-in-schizophrenia 1 ; Completed suicide ; Haplotype analysis
• 刊名：Psychiatry Research
• 出版年：30 January, 2014
• 年：2014
• 卷：215
• 期：1
• 页码：249-251
• 全文大小：188 K

文摘

The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISC1) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide. Enhanced evidence of association was observed in a multi-marker sliding window haplotype analysis (the lowest p=0.002). These findings warrant further studies with a larger sample size to confirm the association of DISC1 with suicide.