In situ detection of estrogen receptor dimers in breast carcinoma cells in archival materials using proximity ligation assay (PLA)

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• 作者：Erina Iwabuchi^a ; Yasuhiro Miki^b ; Katsuhiko Ono^a ; Yoshiaki Onodera^a ; Takashi Suzuki^c ; Hisashi Hirakawa^d ; Takanori Ishida^e ; Noriaki Ohuchi^e ; Hironobu Sasano^a ; ^{hsasano@patholo2.med.tohoku.ac.jp}
• 关键词：Estrogen receptor dimer ; Proximity ligation assay ; Breast carcinoma
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：159-169
• 全文大小：4054 K
• 卷排序：165

文摘

We did firstly succeed in the visualization of ER dimeric proteins using PLA. Estradiol administration induced ERα homodimers in breast carcinoma cell lines. ER dimeric protein was also visualized in clinical specimens of breast cancer.