Simple method for the introduction of iodo-label on (3-trifluoromethyl) phenyldiazirine for photoaffinity labeling

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• 作者：Makoto Hashimoto ; Yuhi Kato and Yasumaru Hatanaka
• 刊名：Tetrahedron Letters
• 出版年：2006
• 出版时间：15 May 2006
• 年：2006
• 卷：47
• 期：20
• 页码：3391-3394
• 全文大小：99 K

文摘

A simple and mild method was developed for the introduction of iodo-label on (3-trifluoromethyl) phenyldiazirine (TPD) aromatic ring in the presence of three membered diazirine ring. An iodination protocol, I₂–BTI in CH₃CN, was found to be effective even though affinity ligands are pre-installed.