Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics
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- 作者：Eiji Yamamoto1 ; Antreas C. Kalli2 ; antreas.kalli@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Kenji Yasuoka1 ; Mark S.P. Sansom2 ; mark.sansom@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：24
- 期：8
- 页码：1421-1431
- 全文大小：4301 K
文摘
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Interactions of 13 different PH domains with PIP-containing membranes are simulated
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PH domains associate with PIPs in membranes via a positively charged loop
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Binding of PH domains causes clustering of PIP molecules within membranes
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Simulations reveal canonical and alternative binding modes of PIPs to PH domains