Genomic Structure and Chromosomal Localization of GML (GPI-Anchored Molecule-like Protein), a Gene Induced by p53

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• 作者：Kimura ; Yasutoshi ; Furuhata ; Tomohisa ; Urano ; Tsutomu ; Hirata ; Koichi ; Nakamura ; Yusuke ; Tokino ; Takashi
• 刊名：Genomics
• 出版年：1997
• 出版时间：May 1, 1997
• 年：1997
• 卷：41
• 期：3
• 页码：477-480
• 全文大小：274 K

文摘

Among its known functions, tumor suppressor gene p53 serves as a transcriptional regulator and mediates various signals through activation of downstream genes. We recently identified a novel gene, GML (glycosylphosphatidylinositol (GPI)-anchored molecule-like protein), whose expression is specifically induced by wildtype p53. To characterize the GML gene further, we determined 35.8 kb of DNA sequence that included a consensus binding sequence for p53 and the entire GML gene. The GML gene consists of four exons, and the p53-binding sequence is present in the 5′-flanking region. In genomic organization this gene resembles genes encoding murine Ly-6 glycoproteins, a human homologue of the Ly-6 family called RIG-E, and CD59; products of these genes, known as GPI-anchored proteins, are variously involved in signal transduction, cell–cell adhesion, and cell–matrix attachment. FISH analysis revealed that the GML gene is located on human chromosome 8q24.3. Genes encoding at least two other GPI-anchored molecules, E48 and RIG-E, are also located in this region.