Variant of the β3-adrenergic receptor gene and coronary atherosclerosis in Japanese subjects
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- 作者：Tamaki ; Shinji ; Iwai ; Naoharu ; Tsujita ; Yasuyuki ; Nakamura ; Yasuyuki ; Ohmichi ; Nobuyuki ; Kinoshita ; Masahiko
- 关键词：Genetics ; β ; 3-Adrenergic receptor gene ; Abdominal obesity ; Insulin resistance ; Ischemic heart disease
- 刊名：International Journal of Cardiology
- 出版年：1999
- 出版时间：June 1, 1999
- 年：1999
- 卷：69
- 期：3
- 页码：309-311
- 全文大小：44.2 K
文摘
In the present study, we assessed the significance of the Trp64Arg mutation in the β3-adrenergic receptor gene in 428 Japanese subjects, including 198 subjects who underwent coronary angiography for possible ischemic heart diseases (IHD group) and 230 non-IHD subjects (control group). We conclude that the Trp64Arg polymorphism of the β3-adrenergic receptor gene did not appear to have any pathophysiological significance in Japanese subjects.