Ruthenium-catalyzed [2 + 2+ 2] cycloaddition of three different alkynes

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• 作者：Yasuyuki Ura ; Yoshitaka Sato ; Hiroshi Tsujita ; Teruyuki Kondo ; Misako Imachi and Take-aki Mitsudo
• 关键词：Ruthenium ; [ ; 2 + 2 + 2] ; Cycloaddition ; Alkynes ; o-Phthalates ; Molar ratio
• 刊名：Journal of Molecular Catalysis A: Chemical
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：239
• 期：1-2
• 页码：166-171
• 全文大小：109 K

文摘

A chemoselective [2 + 2 + 2] cycloaddition of an internal alkyne, a terminal alkyne and dimethyl acetylenedicarboxylate was efficiently catalyzed by Cp^*RuCl(cod) to give trisubstituted o-phthalates in good yield. It is critical to control the molar ratio of the three substrates to achieve high chemoselectivity, and regioselectivity of the products is sensitively influenced by the bulkiness of substituents on the internal alkyne.