Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

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• 作者：Shinji Tamaki ; Yasuyuki Nakamura ; Yasuharu Tabara ; Tomonori Okamura ; Hideyuki K ; a ; Yoshikuni Kita ; Takashi Kadowaki ; Yasuyuki Tsujita ; Tanvir Chowdhury Turin ; Minoru Horie ; Tetsuro Miki ; Hirotsugu Ues
• 刊名：International Journal of Cardiology
• 出版年：2009
• 出版时间：21 August 2009
• 年：2009
• 卷：136
• 期：3
• 页码：354-355
• 全文大小：60 K

文摘

We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7 % ). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95 % confidence interval (CI): 1.10–1.16; p < 0.0001) and sex (HR = 2.18; 95 % CI: 1.23–3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95 % CI: 0.61–2.02; p = 0.731).