Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit

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• 作者：Prem B. Chanda ; Kristopher E. Boyle ; Daniel M. Brody ; Vyom Shukla ; Dale L. Boger ; ^{boger@scripps.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Duocarmycin ; Yatakemycin ; CC-1065 ; DNA alkylation
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：24
• 期：20
• 页码：4779-4786
• 全文大小：1107 K

文摘

The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for the fused pyrrole found in the DNA alkylation subunit.