Sensitive detection of DNA methyltransferase using the dendritic rolling circle amplification-induced fluorescence

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• 作者：Weiling Song ; Yawen Luan ; Xiaoyan Guo ; Peng He ; Xiaoru Zhang ; ^{zhangxr7407@126.com}
• 关键词：DNA methyltransferase ; Dendritic rolling circle amplification ; Fluorescence ; DNA ; DNAzyme
• 刊名：Analytica Chimica Acta
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：956
• 期：Complete
• 页码：57-62
• 全文大小：1211 K
• 卷排序：956

文摘

Mg2+-dependent DNAzyme and signal amplification strategy were implemented for the detection of DNA methyltransferase. The dendritic rolling circle amplification was employed for signal amplified process. This strategy exhibits an excellent specificity and is successfully applied in evaluation of the inhibitors of MTase.