Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade

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• 作者：Chongshan Wang^a ; ¹ ; Qiongren Wang^a ; ¹ ; Xiezhao Li^a ; ^b ; Zhong Jin^a ; ^c ; Peng Xu^a ; ^b ; Naijin Xu^b ; Abai Xu^a ; Yawen Xu^a ; Shaobo Zheng^a ; Junxia Zheng^d ; Chunxiao Liu^a ; Peng Huang^a ; ^b ; ^e ; ^{huangpeng509@gmail.com}
• 关键词：Bladder cancer ; Lycorine ; Phospho-Akt ; Apoptosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：197-202
• 全文大小：991 K
• 卷排序：483

文摘

Lycorine induced the anti-tumor effect in human bladder cancer T24. The cellular mechanisms work by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade. Lycorine may be a promising therapeutic agent against bladder cancer.