A convenient one-pot synthesis of polysubstituted pyrroles from N-protected succinimides

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• 作者：Marwan Kobeissip>ap>p> ; p>p>marwan.kobeissi@liu.edu.lb" class="auth_mailp> ; Ogaritte Yazbeckp>bp>p> ; p>p>ogaritte.yazbek@liu.edu.lb" class="auth_mailp> ; Yamama Chreimp>cp>p> ; p>p>ychreim@ul.edu.lb" class="auth_mailp>
• 关键词：Dienamines ; Petasis reagent ; Methylenation ; Succinimides ; Polysubstituted pyrroles
• 刊名：Tetrahedron Letters
• 出版年：9 April, 2014
• 年：2014
• 卷：55
• 期：15
• 页码：2523-2526
• 全文大小：3109 K

文摘

The dienamine products formed by the reaction between polysubstituted succinimides and the Petasis reagent were subjected to isomerization under mild acidic conditions to give polysubstituted pyrroles in excellent yields (85-95%). The scope and limitations of this methodology are explored.