Discovery of indeno[1,2-b]quinoxaline derivatives as potential anticancer agents
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- 作者：Chih-Hua Tsenga ; b ; c ; You-Ren Chend ; Cherng-Chyi Tzengb ; c ; d ; Wangta Liue ; Chon-Kit Choue ; Chien-Chih Chiue ; f ; cchiu@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Yeh-Long Chenb ; c ; d ; yeloch@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Indeno[1 ; 2-b]quinoxaline derivatives ; Zebrafish xenograft assay ; Anticancer agents ; Cell cycle ; Apoptosis ; Antiproliferative activity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：27 January 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：258-273
- 全文大小：2505 K
文摘
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Novel series of indeno[1,2-b]quinoxaline derivatives were synthesized.
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Most indeno[1,2-b]quinoxalines exhibited potent cytotoxicity against cancer cells.
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Compound 10a induced S-phase arrest and apoptosis in Huh-7 cells.
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Compound 10a inhibited tumor growth in the Huh-7 tumor zebrafish xenograft model.