Decreased HCRP1 promotes breast cancer metastasis by enhancing EGFR phosphorylation
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- 作者：Wenlin Yanga ; 1 ; Ji-Gang Wanga ; b ; 1 ; Qiangxiu Wangc ; Yejun Qinc ; Xiaoyan Linc ; Danmei Zhoua ; Kehan Rena ; Chenjian Houa ; Jiawen Xuc ; 4366203@qq.com" class="auth_mail" title="E-mail the corresponding author ; Xiuping Liua ; d ; xpliu1228@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCRP1 ; EGFR ; Breast cancer ; Metastasis ; VPS37A
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 August 2016
- 年：2016
- 卷：477
- 期：2
- 页码：222-228
- 全文大小：2857 K
文摘
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HCRP1 expression is decreased in breast cancer tissues and cell lines.
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HCRP1 depletion contributes to breast cancer migration and invasion.
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HCRP1 depletion decreases EGFR degradation and enhances EGFR phosphorylation in breast cancer.
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HCRP1 depletion contributes to insensitivity of anti-EGFR targeted therapy in breast cancer.