Primary extranodal non-Hodgkin lymphoma of head and neck: the experience in twenty-eight patients
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文摘
Our purpose is to report the experience in 28 primary extranodal non-Hodgkin lymphomas of head and neck during the period from March 1990 to February 1995. Extranodal involvements were tonsils in 13(46 % ), parotid in 3(11 % ), pharynx in 6(18 % ), nasal cavity in 2(8 % ), oral cavity in 3(11 % ), and paranasal sinus in 1(4 % ) patient. Histologic grading could not be identified in 2 patients, but fifteen patients(58 % ) were in intermediate and 11 patients(42 % ) were in low-grade. Distribution of stages in 26 patients were as following; 14(54 % ) in stage I, 9(35 % ) in stage II, 1(4 % ) in stage III, and 2(8 % ) in stage IV. Of the 22 patients treated, 14(64 % ) received both chemotherapy and radiotherapy, 7(32 % ) received only chemotherapy and 1(5 % ) received only radiotherapy. Half of the patients were given CNOP regimen and the rest were given various regimens i.e m-BACOD, BACOP, COP, and CHOP. Overall response rate was 90 % (58 % complete and 32 % partial response) and median survival duration was 18 months(ranged from 6 to 59). Prominent toxicity was myelosuppression(22 % ).