A novel polysaccharide from Trichosanthes peel was isolated for the first time.
The molecular weight of TPP-1 was 1.2 × 105 Da.
The backbone of TPP-1 was composed of 1,4,6-Galp, 1,4-Galp, 1,3,6-Manp and 1,4-Manp.
The branches of TPP-1 consisted of 1,3-Araf, 1-Araf and 1-Glcp.
TPP-1 possessed significant hypoglycemic activities.