Anticoagulant activity of a sulfated Lachnum polysaccharide in mice with a state of hypercoagulability
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- 作者：Zhanzhan Dua ; &dagger ; ; Fang Shia ; &dagger ; ; Dong Liub ; Hongling Yeb ; Maheen Mahwish Surhioa ; Jinglei Lia ; Ming Yea ; yeming123@sina.com" class="auth_mail" title="E-mail the corresponding author ; yeming59@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lachnum polysaccharide ; Sulfation ; Anticoagulant activity
- 刊名：Bioorganic & Medicinal Chemistry Letters
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：26
- 期：22
- 页码：5550-5556
- 全文大小：1025 K
文摘
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Sulfated polysaccharide SLEP-1 was prepared from LEP-1.
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SLEP-1 could more effectively prolong APTT and TT of the normal mice than those of LEP-1.
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SLEP-1 showed strong inhibitory effect on intrinsic coagulation pathway and could also enhance fibrinolytic activity.