The stimulation of the differentiation of pheochromocytoma (PC12-L) cells into neuron-like cells by electrically conductive nanofibre mesh

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• 作者：Huishang Yang^a ; ^b ; ¹ ; Guanglin Zhu^a ; ^b ; ¹ ; Yicheng Huang^a ; ^b ; Xuetao Shi^b ; ^{shxt@scut.edu.cn} ; Yingjun Wang^a ; ^{imwangyj@163.com}
• 关键词：Nanofiber mesh ; Polycaprolactone ; Polyaniline ; Cell differentiation
• 刊名：Applied Materials Today
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：215-222
• 全文大小：4475 K
• 卷排序：5

文摘

This study reports a novel method in which polycaprolactone(PCL)/polyaniline(PANi) nanofibre mesh is used to promote the differentiation of pheochromocytoma (PC12-L) cells into neuron-like cells. Stainless steel wire mesh (304) was used as a collector in the rapid fabrication of alignment-patterned PCL/PANi nanofibre mesh. Successful incorporation of PANi improved the electrical conductivity of the nanofibre mesh. Culturing low-differentiated rat pheochromocytoma (PC12-L) cells on the electrically conductive nanofibre mesh significantly promoted the differentiation of PC12-L cells into neuron-like cells by the synergetic effect of the alignment patterns and the electrical conductivity of PANi. The electrically conductive nanofibre mesh described in this study may provide a promising platform for the study of nerve regeneration.