Fish IRF3 up-regulates the transcriptional level of IRF1, IRF2, IRF3 and IRF7 in CIK cells
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- 作者：Xiaowen Xua ; 1 ; Qinan Laia ; b ; 1 ; Meihui Gua ; Dan Liua ; Qunhao Houa ; Xiancheng Liua ; Yichuan Mia ; Zhicheng Suna ; Haizhou Wanga ; Gang Lina ; Chengyu Hua ; hucy2008@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：IRF3 ; Transcriptional control ; Promoter ; ISG ; Fish
- 刊名：Fish & Shellfish Immunology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：47
- 期：2
- 页码：978-985
- 全文大小：1097 K
文摘
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The full-length cDNA and the promoter sequences of grass carp IRF3 were cloned and identified.
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CiIRF3 had a conserved DNA binding domain (DBD), an IRF association domain (IAD) and shared high homology with CaIRF3.
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CiIRF3 was ubiquitously expressed at low level but was obviously up-regulated under the induction of Poly I:C.
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CiIRF3 bound to CiIRF1, CiIRF2, CiIRF3 and CiIRF7 promoters with high affinity.
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CiIRF3 acted as a positive regulator for the transcription of CiIRF1, CiIRF2, CiIRF3 and CiIRF7.