T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-γ Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma
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- 作者：Qiang Zou1 ; 2 ; Jin Jin2 ; 4 ; Yichuan Xiao2 ; 5 ; Xiaofei Zhou2 ; Hongbo Hu2 ; 6 ; Xuhong Cheng2 ; Nasser Kazimi2 ; Stephen E. Ullrich2 ; 3 ; Shao-Cong Sun2 ; 3 ; ssun@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：tumor microenvironment ; IFN-γ ; USP15 ; T cells ; immunosuppression
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：22 December 2015
- 年：2015
- 卷：13
- 期：11
- 页码：2470-2479
- 全文大小：2589 K
文摘
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USP15 deficiency renders mice more sensitive to MCA-induced fibrosarcoma
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USP15-deficient T cells promote MCA-induced primary tumor formation
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T cell-derived IFN-γ induces an immunosuppressive tumor microenvironment
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Targeting PD-L1 or CXCL12 reduces MCA-induced tumorigenesis in USP15-deficient mice