The role of GRIN2B in Tourette syndrome: Results from a transmission disequilibrium study
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- 作者：Fengyuan Chea ; b ; Ying zhangc ; Guiju Wangd ; Xueyuan Hengb ; Shiguo Liue ; liushiguo2002@126.com" class="auth_mail" title="E-mail the corresponding author ; Yifeng Dua ; duyifengpmd2000@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：TS ; Grin2B ; TDT ; HRR
- 刊名：Journal of Affective Disorders
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：187
- 期：Complete
- 页码：62-65
- 全文大小：266 K
文摘
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We examined whether two functional polymorphisms (rs1805476 and rs1805502) in the 3′UTR of the NMDA receptor 2B subunit gene (GRIN2B) were associated with TS in Chinese Han trios.
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The genotype data of 261 TS nuclear families were analyzed by Haplotype relative risk (HRR), transmission disequilibrium test (TDT) and Haplotype-based haplotype relative risk (HHRR).
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We found an over-transmission of the A allele in rs1805476 and the T allele in rs1805502 from parents to their affected children.