Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production
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- 作者：Anne P. Liao ; Mohammad Salajegheh ; Chris Morehouse ; Remedios Nazareno ; Ronald G. Jubin ; Bahija Jallal ; Yihong Yao ; Steven A. Greenberg
- 关键词：Type 1 interferons ; Systemic lupus erythematosus ; Myositis ; Plasmacytoid dendritic cells
- 刊名：Clinical Immunology
- 出版年：2010
- 出版时间：July 2010
- 年：2010
- 卷：136
- 期：1
- 页码：130-138
- 全文大小：775 K
文摘
To determine the potential consequences of plasmacytoid dendritic cell (pDC) accumulation in tissue sites observed in several autoimmune diseases, we measured type 1 interferon production from circulating human pDCs as a function of pDC concentration. The effects of interferon-alpha and blockade of the type 1 interferon receptor (IFNAR) on human pDC type 1 interferon and interferon-inducible transcription and protein production were measured. Human pDCs became far more efficient producers of interferon-alpha at concentrations beyond those normally present in blood, through an IFNAR-dependent mechanism. Extracellular interferon-alpha increased pDC production of type 1 interferons. The accumulation of pDCs in diseased tissue sites allows marked non-linear amplification of type 1 interferon production locally. The role of the IFNAR-dependent mechanism of interferon production by human pDCs is greater than previously suggested. IFNAR blockade has potential for diminishing type 1 interferon production by all human cells.