Downregulation of miR-638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC
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- 作者：Yang Xia1 ; Yanhu Wu1 ; Bin Liu ; Pengli Wang ; Yijiang Chen ; YJChen@NJMU.edu.cn" class="auth_mail
- 关键词：miR-638 ; SRY (sex determining region Y)-box 2 ; Proliferation ; Invasion ; Epithelial-to-mesenchymal transition ; Non-small-cell lung cancer
- 刊名：FEBS Letters
- 出版年：27 June 2014
- 年：2014
- 卷：588
- 期：14
- 页码：2238-2245
- 全文大小：3325 K
文摘
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Expression of miR-638 is reduced in lung cancer tissues.
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Downregulation of miR-638 is related to the invasion and proliferation of lung cancer cell lines.
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Direct binding of miR-638 to the SOX2 3′-UTR is confirmed.
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miR-638 overexpression diminishes but miR-638 knockdown increases SOX2 expression levels in vitro.
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Aberrant expression of miR-638 is related to invasion and proliferation of NSCLC by regulating SOX2.