Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer
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- 作者：Pradeep Chaluvally-Raghavan1 ; 8 ; pchaluvally@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Kang Jin Jeong1 ; Sunila Pradeep2 ; 3 ; Andreia Machado Silva4 ; Shuangxing Yu1 ; Wenbin Liu5 ; Tyler Moss1 ; Cristian Rodriguez-Aguayo4 ; Dong Zhang1 ; Prahlad Ram1 ; Jinsong Liu6 ; Yiling Lu1 ; Gabriel Lopez-Berestein4 ; 7 ; George A. Calin4 ; 7 ; Anil K. Sood2 ; 3 ; 7 ; Gordon B. Mills1 ; gmills@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：15
- 期：7
- 页码：1493-1504
- 全文大小：3232 K
文摘
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3q26.2 copy-number alterations associate with miR551b-3p expression
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miR551b-3p interacts with the STAT3 promoter and activates STAT3 transcription
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miR551b-3p is an oncogenic microRNA that enhances tumor growth in vitro and in vivo
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Therapeutic delivery of anti-miR551b reduces tumor growth in vivo