Interleukin-21 administration leads to enhanced antigen-specific T cell responses and natural killer cells in HIV-1 vaccinated mice
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- 作者：Bin Jua ; Dan Lia ; Xiaolin Jia ; Jiandong Liua ; Hong Penga ; Shuo Wanga ; Ying Liua ; Yanling Haoa ; Cassian Yeeb ; Hua Lianga ; lianghua777@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yiming Shaoa ; yshao08@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIV-1 vaccine ; Immune responses ; Multifunction ; Cytokine adjuvant ; IL-21
- 刊名：Cellular Immunology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：303
- 期：Complete
- 页码：55-65
- 全文大小：2795 K
文摘
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Mouse IL-21 could not increase antibody binding capacity to HIV-1 GP140.
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Mouse IL-21 enhanced Th1 type immune response.
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Mouse IL-21 increased the percentages of HIV-1 specific CD4+ T and CD4+ TEM cells.
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Mouse IL-21 increased HIV-1 specific multifunctional CD4+ T and CD4+ TEM cells.
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Mouse IL-21 increased the frequency of NK cells.