Strain-controlled low cycle fatigue (LCF) experiments of a second generation single crystal (SC) nickel-base superalloy are carried out to investigate the effect of crystallographic orientations on its LCF life. Further, the life modeling of the SC superalloy is considered by employing the modified M眉cke鈥檚 anisotropic model. The results show that the LCF life of the SC superalloy has a strong crystallographic orientation dependence; the local strain approach fails to predict the fatigue life but the modified M眉cke鈥檚 anisotropic model is able to predict the fatigue life for the SC superalloy at the three characteristic orientations simultaneously.