Preparation of a novel starch-derived three-dimensional ordered macroporous carbon for improving the dissolution rate and oral bioavailability of water-insoluble drugs
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- 作者：Ying Liu ; Chao Wu ; wuchao27@126.com" class="auth_mail" title="E-mail the corresponding author ; Yanna Hao ; Jie Xu ; Ying Zhao ; Yang Qiu ; Jie Jiang ; Tong Yu ; Peng Ji
- 关键词：Starch ; Three-dimensional ordered macroporous carbon ; Felodipine ; Insoluble drug ; Dissolution rate ; Relative oral bioavailability
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：267-275
- 全文大小：1873 K
文摘
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3DOMC is prepared and used to improve the solubility and bioavailability of drugs.
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When combined with osmotic pump technology, the drug release rate can be regulated.
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3DOMC can inhibit the crystallization of drugs and maintain them in an amorphous state.