Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia

详细信息    查看全文

• 作者：Xiao-Ying Wang^a ; ^b ; Gui-Hua Tang^b ; Chun-Mao Yuan^b ; Yu Zhang^b ; Tao Zou^a ; Chun Yu^a ; Qing Zhao^a ; ^{tempzhao@126.com} ; Xiao-Jiang Hao^b ; ^{haoxj@mail.kib.ac.cn} ; Hong-Ping He^a ; ^b ; ^{hehongping@mail.kib.ac.cn}
• 关键词：Aphanamixis grandifolia ; Meliaceae ; Cycloartane triterpenoids ; Antibacterial activities
• 刊名：Fitoterapia
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：85
• 期：Complete
• 页码：64-68
• 全文大小：644 K

文摘

Three new cycloartane triterpenoids, aphagrandinoids A-C (1-3), and a new natural product, aphagrandinoid D (4), together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS techniques. Aphagrandinoid A (1), a 29-nor-cycloart triterpenoid, features with a sprio ring system at the side chain, while aphagrandinoid C (3) is a pentnortriterpenoid. Antibacterial activities of these five compounds were also evaluated. Compounds 1 and 5 showed weak antibacterial activities (MIC values: 1.57-3.13 ¦Ìg/mL) against Staphylococcus aureus, MRSA 92^#, and MRSA 98^#.