House dust mite extract induces growth factor expression in nasal mucosa by activating the PI3K/Akt/HIF-1α pathway
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- 作者：Xi Chena ; Ying-Ying Lia ; Wei-Qiang Zhanga ; Wei-Ming Zhangb ; Han Zhoua ; zhouhan1979@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allergic rhinitis ; Hypoxia-inducible factor 1 ; Growth factor ; PI3K ; Signaling pathway ; Nasal mucosa
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：469
- 期：4
- 页码：1055-1061
- 全文大小：1659 K
文摘
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House dust mite extract induces growth factor expression in nasal mucosa.
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The role of PI3K/Akt/HIF-1α pathway in allergic rhinitis was investigated.
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HIF-1 regulates the expression of VEGF, TGF-β1, and FGF-2 in nasal epithelial cell.