Upregulation of soluble B7-H3 in NSCLC-derived malignant pleural effusion: A potential diagnostic biomarker correlated with NSCLC staging
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- 作者：Liwen Chena ; Guangbo Zhangb ; Shouqin Shengc ; Qiang Zhoua ; Ying Pana ; Shihe Guana ; shiheguan@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MPEs ; malignant pleural effusions ; NPEs ; nonneoplastic pleural effusions ; sB7-H3 ; soluble B7-H3 ; CEA ; carcino-embryonic antigen ; CYFRA21-1 ; Cytokeratin 19 fragment
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：457
- 期：Complete
- 页码：81-85
- 全文大小：521 K
文摘
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sB7-H3 is upregulated in NSCLC-derived malignant pleural effusions (MPEs).
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Sera and cognate MPEs have comparable and closely correlated sB7-H3 expression.
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MPEs-derived sB7-H3 has equal diagnostic effectiveness with CEA and CYFRA21-1.
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MPEs-derived sB7-H3 is correlated with smoking status and TNM stage of NSCLC.