Transcranial direct current stimulation of the frontal-parietal-temporal area attenuates cue-induced craving for heroin

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• 作者：Yingjie Wang^a ; ^b ; ¹ ; Ying Shen^c ; ¹ ; Xinyu Cao^d ; ¹ ; Chunlei Shan^e ; ¹ ; Jibin Pan^d ; Hao He^d ; Yuanye Ma^f ; ^{yuanma0716@vip.sina.com" class="auth_mail" title="E-mail the corresponding author} ; Ti-Fei Yuan^a ; ^{ytf0707@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Transcranial direct current stimulation ; Heroin ; Craving ; Frontal-parietal-temporal area
• 刊名：Journal of Psychiatric Research
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：79
• 期：Complete
• 页码：1-3
• 全文大小：398 K

文摘

Transcranial direct current stimulation (tDCS) is an effective approach to modulate brain region functions. We assessed if a single tDCS session over the bilateral frontal-parietal-temporal (FPT) areas would reduce cue induced craving in heroin addicts.

Methods

Twenty non-treated, long-term heroin-addicted subjects were randomly assigned to receive either real tDCS (1.5 mA, cathodal over bilateral FPT for 20 min) or control tDCS stimulation (turning off the stimulation after 30 s). The participants received heroin cue exposure (containing both injection and inhalation procedures) before and after stimulation and rated their craving after each block of cue presentation.

Results

Stimulation of the bilateral FPT with real tDCS for 20 min reduced craving scores significantly (68 ± 8.4 pre-stimulation vs. 43 ± 7.6 post-stimulation, p = 0.003), while the control stimulation group showed no significant changes. No side effects of tDCS were reported.

Conclusions

One session of tDCS over bilateral FPT area significantly reduced subjective craving score induced by heroin cues in heroin addicted subjects.