Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters
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- 作者：Afsaneh Goudarzi1 ; 8 ; Di Zhang2 ; 8 ; He Huang2 ; Sophie Barral1 ; Oh Kwang Kwon2 ; Shankang Qi2 ; Zhanyun Tang3 ; Thierry Buchou1 ; Anne-Laure Vitte1 ; Tieming He4 ; Zhongyi Cheng4 ; Emilie Montellier1 ; Jonathan Gaucher1 ; 5 ; Sandrine Curtet1 ; Alexandra Debernardi1 ; Guillaume Charbonnier6 ; Denis Puthier6 ; Carlo Petosa7 ; Daniel Panne5 ; Sophie Rousseaux1 ; Robert G. Roeder3 ; Yingming Zhao2 ; 9 ; yzhao2@bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author ; Saadi Khochbin1 ; 9 ; saadi.khochbin@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：62
- 期：2
- 页码：169-180
- 全文大小：3536 K
文摘
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Active gene TSSs are marked by competing H4 K5K8 acetylation and butyrylation
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Histone butyrylation directly stimulates transcription
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H4K5 butyrylation prevents binding of the testis specific gene expression-driver Brdt
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H4K5K8 butyrylation is associated with delayed histone removal in spermatogenic cells