Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression
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- 作者：Shang-Jui Wang1 ; 3 ; Dawei Li1 ; 3 ; Yang Ou1 ; Le Jiang1 ; Yue Chen2 ; 4 ; Yingming Zhao2 ; Wei Gu1 ; 5 ; wg8@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：p53 ; acetylation ; deacetylation ; ferroptosis ; metabolic regulation ; transcription ; SLC7A11 ; tumor suppression
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：366-373
- 全文大小：1723 K
文摘
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CBP acetylates human p53 at K101 and mouse p53 at K98
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K98 acetylation of mouse p53 contributes to regulation of certain metabolic genes
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p534KR98 is defective in suppressing tumor growth
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Ferroptosis and repression of SLC7A11 are defective in p534KR98-expressing cells