Chronic mild stress-induced changes of risk assessment behaviors in mice are prevented by chronic treatment with fluoxetine but not diazepam
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- 作者：Che Wang ; Min Li ; Darrell Sawmiller ; Yaxin Fan ; Yinghua Ma ; Jun Tan ; Yiwei Ren ; Song Li
- 关键词：Chronic mild stress ; Risk assessment ; Decision making ; Serotonin ; 纬-Aminobutyric acid
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：January, 2014
- 年：2014
- 卷：116
- 期：Complete
- 页码：116-128
- 全文大小：872 K
文摘
As an important part of risk-related defensive behavior and central element of anxiety, risk assessment in rodents is particularly sensitive to psychosocial stress and may consequently influence the following decision-making and behavioral output. In this study, using a mouse-test battery, we evaluated the possible impacts of chronic mild stress (CMS) on risk assessment behaviors and action selections. For non-stressed control animals, a close relationship between risk assessment and choice behavior was observed in EPM and LDT. For stressed animals, however, 5 weeks of CMS exposure not only increased risk assessment behaviors, but also abolished the correlations between risk assessment and action selection. Pharmacological intervention with GABA-A receptor modulator diazepam (0.25-4 mg/kg) blocked the alterations of conventional spatiotemporal behaviors in response to CMS, but had no effect on the CMS-induced risk assessment behavioral changes. In contrast, 4-weeks of chronic treatment with fluoxetine (4-20 mg/kg), a selective serotonin reuptake inhibitor, not only ameliorated the CMS-affected risk-assessment behaviors, but also restored the CMS-impaired correlations between risk assessment and decision making-related action selection. The present findings may shed new light on the better understanding of emotional reactivity and decision making under stressful situations. These results also indicate a differential pharmacological sensitivity in CMS-affected emotional response and risk-assessment behaviors.