Astragaloside IV enhances diabetic wound healing involving upregulation of alternatively activated macrophages
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- 作者：Xiaochun Luoa ; b ; Ping Huanga ; b ; Baohong Yuanb ; Tao Liuc ; Fang Lanb ; Xiaoyan Lub ; Liangcheng Daid ; Yunjun Liue ; lyjche@163.com" class="auth_mail" title="E-mail the corresponding author ; Hui Yinb ; c ; huiyin0103@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Astragaloside IV ; Diabetes ; Wound healing ; Extracellular matrix ; Alternatively activated macrophages
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：22-28
- 全文大小：1155 K
文摘
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We examined the role of Astragaloside IV (AS-IV) on impaired wound healing in streptozotocin-induced diabetic mice.
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Administration of AS-IV accelerates diabetic wound healing.
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AS-IV promotes collagen deposition and ECM synthesis.
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AS-IV improved the new blood vessel formation in wound tissue.
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The effect of AS-IV is associated with upregulation of alternatively activated macrophages (AAM).