Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older

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• 作者：Ylva Kö ; hncke^a ; ^{ylva.kohncke@ki.se" class="auth_mail" title="E-mail the corresponding author} ; Erika J. Laukka^a ; Yvonne Brehmer^a ; ^b ; Gré ; goria Kalpouzos^a ; Tie-Qiang Li^c ; Laura Fratiglioni^a ; ^d ; Lars Bä ; ckman^a ; Martin Lö ; vdé ; n^a ; ^e
• 关键词：Leisure activities ; White matter microstructure ; Perceptual speed ; Longitudinal ; Structural equation modeling
• 刊名：Neurobiology of Aging
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：41
• 期：Complete
• 页码：173-186
• 全文大小：1170 K

文摘

Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we investigated the role of change in white matter microstructure in the activities-cognition link. We used repeated assessments of engagement, perceptual speed, and white matter microstructure (probed with diffusion tensor imaging) in a population-based sample of individuals over 80 years without dementia (n = 442, M_age = 85.1; n = 70 for diffusion tensor imaging; 2 occasions 3 years apart). Using multivariate latent change modeling, we observed positive correlations among changes in predominantly social activities, white matter microstructure, and perceptual speed. Interindividual differences in change in white matter microstructure statistically accounted for the association between change in leisure activities and change in perceptual speed. However, as analyses are based on observational data from 2 measurement occasions, causality remains unclear.