Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection
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- 作者：Laura J. Yockey1 ; Luis Varela2 ; Tasfia Rakib1 ; William Khoury-Hanold1 ; Susan L. Fink1 ; 3 ; Bernardo Stutz2 ; Klara Szigeti-Buck2 ; Anthony Van den Pol4 ; Brett D. Lindenbach5 ; Tamas L. Horvath2 ; Akiko Iwasaki1 ; 6 ; 7 ; akiko.iwasaki@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：sexually transmitted infections ; mucosal immunity ; antiviral defense ; type I interferons ; female reproductive tract ; flavivirus ; innate immunity ; pattern recognition receptors
- 刊名：Cell
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：166
- 期：5
- 页码：1247-1256.e4
- 全文大小：1779 K
文摘
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Zika virus replicates in the vaginal tract of wild-type virgin and pregnant mice
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Innate RNA sensors and type I interferons control vaginal Zika virus replication
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Vaginal Zika virus infection in early pregnancy leads to fetal growth restriction
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Vaginal Zika virus infection of pregnant dams leads to fetal brain infection