Synthesis of substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylate from a common acyclic precursor employing C-formylation strategy

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• 作者：Goraksha Khose ; Shailesh Shinde ; Anil Panmand ; Ravibhushan Kulkarni ; Yogesh Munot ; Anish Bandyopadhyay ; Dinesh Barawkar ; Santoshkumar N. Patil ; ^{santosh.patil@advinus.com" class="auth_mail}
• 关键词：C-formylation of glycine ethyl ester ; Substituted esters of imidazoles ; Substituted esters of oxazoles ; Substituted esters of thiazoles ; Diethyl pyrazine-2 ; 5-dicarboxylate synthesis ; Common acyclic precursor
• 刊名：Tetrahedron Letters
• 出版年：16 April, 2014
• 年：2014
• 卷：55
• 期：16
• 页码：2671-2674
• 全文大小：2096 K

文摘

A novel synthetic route to substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylates via C-formylation of glycine ethyl ester hydrochloride is reported. This methodology is simple, robust, and gives good yields of different heterocyclic esters in one or two steps from a common acyclic precursor and is amenable to large scale synthesis.